Metabolomics | Lipidomics Services

We provide Targeted Metabolomics/Lipidomics, the measurement of defined groups of chemically characterized and biochemically annotated metabolites. Nitrogenous metabolites, including the amino acids, lipids, and intermediary metabolites, including the TCA cycle oxoacids, from body fluids, tissues, cells, and fecal can be measured. There is a method development cost to establish the custom assay that varies depending on the number of metabolites to target, different matrix testing, and whether or not you want quantitation

Pricing

WashU: Starting at $ (Once assay has developed)

External Academic/Nonprofit: Starting at $ (Once assay has developed)

External For-Profit Industry: Starting at $ (Once assay has developed)

Instruments Used

Orbitrap ID-X

Orbitrap Exploris 240

Untargeted (Global) Metabolomics/Lipidomics, an intended comprehensive analysis of all the measurable analytes in a sample including chemical unknowns. MTAC employs multiple columns, mobile phases and ion modes togetehr with databased contain >1.5M features to cast in-depth profiling of compounds in various sample types including body fluids, tissues, cells, and fecal from any species. 

MTAC Offers:

1-, 2- ,3- or 4-columns system.

Pricing

WashU: Starting at $ (Once assay has developed)

External Academic/Nonprofit: Starting at $ (Once assay has developed)

External For-Profit Industry: Starting at $ (Once assay has developed)

Instruments Used

Orbitrap ID-X

Orbitrap Exploris 240

Metabolic flux is the passage of a metabolite through a given pathway over time. Metabolic flux analysis using stable isotopes such as 2H, 13C, and 15N (e.g., 13C-labeled glucose) enables identifying and quantitatively estimating the metabolism through metabolic pathways by observing the position of the isotopic label along the metabolic pathways and can reveal differences in glucose metabolism between healthy cells and cancer cells.

This technique helps researchers understand how cancer cells rewire their metabolism to support their growth and survival, potentially uncovering new targets for therapeutic intervention.

Pricing

WashU: Starting at $ (Once assay has developed)

External Academic/Nonprofit: Starting at $ (Once assay has developed)

External For-Profit Industry: Starting at $ (Once assay has developed)

Instruments Used

Orbitrap ID-X

Orbitrap Exploris 240

Work performed by the MTAC should be acknowledged as shown below:

"Mass Spectrometry analyses were performed by the Mass Spectrometry Technology Access Center at the McDonnell Genome Institute (MTAC@MGI) at Washington University School of Medicine, supported by the Diabetes Research Center/NIH grant P30 DK020579, Institute of Clinical and Translational Sciences/NCATS CTSA award UL1 TR002345, and Siteman Cancer Center/NCI CCSG grant P30 CA091842."

Contact MassSpec@wustl.edu to get more information