Proteogenomics

Proteogenomics is at the interface of proteomics and genomics.

MTAC is the first mass spec center that can provide Proteomgenomics and the most current technologies used to generate, analyze, and integrate proteomics with genomics data on the frontier of precision medicine.


WashU’s McDonnell Genome Institute (MGI) hosts both the MTAC and the GTAC (Genome Technology Access Center). GTAC is a nationally recognized leading genomics core facility providing microRNA (miRNA), RNA sequencing (RNA-seq), whole-genome sequencing (WGS), and whole-exome sequencing (WXS), which are genomic data types typically available in proteogenomic study. Under the MGI umbrella, we, the MTAC and GTAC, can closely facilitate proteogenomics efforts to identify and quantify proteins and PTMs modulated in cancer/disease and correlate them to copy number variations, epigenetic silencing and changes in miRNA expression. Genomic and transcriptional profiling provides a read on the character and potential impact of genomic alterations, whereas proteomics provides direct information on protein modulation and signaling in response to those changes.


Proteogenomic discovery of neoantigens facilitates personalized multi-antigen targeted T cell immunotherapy for brain tumors

Orbitrap ID-X Tribrid

Proteogenomic convergence for understanding pathways and networks

Proteogenomic characterization of glioblastomas

Orbitrap Eclipse™ Tribrid™ with FAIMS

The Thermo Scientific Orbitrap Eclipse mass spectrometer incorporates the latest inventions in ion transmission and control, extended m/z range, and real-time decision making to expand the breadth of your work and push your science beyond today's discovery. This system is ideally suited for proteomics, structural biology, small-molecule, and biopharmaceutical characterization experiments.

Read More...

Orbitrap Exploris™ 480 Biopharma with FAIMS

Maximize high-throughput performance in proteomics and biopharma applications with the Thermo Scientific Orbitrap Exploris 480 mass spectrometer. Where next level exploration delivers quantifiable accuracy, and selectivity required to obtain richer insights. Empowering translational scientists by bringing performance and intelligence together, the switch between exploration and targeted quantitation has never been easier. Suddenly your work goes deeper and even the routine will become simple, certain and extraordinary.

Read More...


Orbitrap Exploris™ 240

From small- to large-molecule analyses, the Thermo Scientific Orbitrap Exploris 240 mass spectrometer delivers performance and versatility to drive discovery and identification with the quantitative precision and accuracy to confidently scale up while achieving impact.

Read More...


Proteogenomics microprotein discovery pipeline

From small- to large-molecule analyses, the Thermo Scientific Orbitrap Exploris 240 mass spectrometer delivers performance and versatility to drive discovery and identification with the quantitative precision and accuracy to confidently scale up while achieving impact.

Read More...